Fig. 5.

(A) Effects of endocytosis inhibitors on cellular uptakes of Dox/HCVs were studied by flow cytometry: Hela cells were incubated with medium containing fixed Dox concentration formulations without (a, control; b, at 4 °C) or with 10 mg/ml chlorpromazine(c), 8 mg/ml colchicine(d), 6 mg/ml indomethacin(e) and 6 mg/ml quercetin (f) for 3 h after pretreated with inhibitors for 1 h at 37 °C. (B) Effect of competitive inhibition of free HA (MW 102 kDa, 5 mg/ml) on cellular uptake of Dox/HCVs at 37 °C for 3 h.