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Pharmacokinetic parameters for CBZ-NPs and CBZ-SL after intranasal administration (n = 3).
| Parameters | CBZ-NPs |
CBZ-SL |
||
|---|---|---|---|---|
| Plasma | Brain tissue | Plasma | Brain tissue | |
| Tmax(min) | 50.2 ± 11.48 | 41.4 ± 13.32 | 32.1 ± 4.64 | 36.0 ± 8.12 |
| Cmax(µg/ml) | 0.23 ± 0.10 | 0.50 ± 0.13 | 0.15 ± 0.02 | 0.11 ± 0.04 |
| AUC0–∞(min·µg/ml) | 36.28 ± 3.17 | 93.01 ± 2.35 | 13.88 ± 1.07 | 7.51 ± 0.65 |
| MRT(min) | 89.4 ± 10.1 | 138.6 ± 11.5 | 41.4 ± 9.1 | 53.4 ± 4.4 |
