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The effect of KCs depletion on the pharmacokinetics and biodistribution of PL induced ABC phenomenon. Depleted rats or normal rats were administered PL at a dose of 15 µmol phospholipids/kg or 5% glucose solution. After 7 d, they were injected with PL of the test dose. (A) Pharmacokinetic profile. (B) Quantitative analysis of the liver and spleen in rats 24 h after intravenous administration. Data are represented as mean ± SD, n = 3 (*P < 0.05, **P < 0.01).
