. 2017 Jul 12;12(6):509–520. doi: 10.1016/j.ajps.2017.07.005

Table 4.

Mathematic modeling and drug release kinetics from microbeads, analyzed by regression coefficient method.

Formulation	Zero order R²	First order R²	Higuchi R²	Korsmeyer–Peppas
Formulation	Zero order R²	First order R²	Higuchi R²	R²	n
Medium without reducing agent
Microbeads containing thiolated HMP−DOX conjugate	0.938	0.838	0.471	0.974^a	0.87
Microbeads containing thiolated LMP−DOX conjugate	0.948	0.648	0.762	0.976^a	0.85
Medium with reducing agent (DTT)
Microbeads containing thiolated HMP−DOX conjugate	0.980^a	0.825	0.816	0.973	0.67
Microbeads containing thiolated LMP−DOX conjugate	0.926^a	0.879	0.677	0.792	0.58
DOX-loaded thiolated HMP microbeads	0.827	0.570	0.909	0.942^a	0.56
DOX-loaded thiolated LMP microbeads	0.839	0.765	0.917	0.956^a	0.44

The highest correlation coefficient (R²), compared to other models.