. 2018 Sep 24;14(5):531–542. doi: 10.1016/j.ajps.2018.08.009

Table 3.

Non-compartmental analysis of plasma data for PTX in rats after i.v. administration of HA-SS-ATRA₂₁/PTX, HA-ATRA₂₀/PTX and Taxol^® (mean ± SD, n = 5).

Pharmacokinetic parameters	HA-SS-ATRA₂₁/PTX	HA-ATRA₂₀/PTX	Taxol^®
AUC₀₋_t (h.µg/ml)	36.86 ± 5.64^**	34.07 ± 1.29^**	4.02 ± 0.06
T_1/2 (h)	69.11 ± 24.30	108.44 ± 73.95	8.49 ± 1.32
MRT (h)	20.95 ± 1.29^**	21.86 ± 0.46^**	3.21 ± 0.02
CL (ml/h/kg)	55.84 ± 30.80^**	35.59 ± 13.64^**	649.48 ± 31.50
V_d (ml/kg)	5250.93 ± 112.98	6278.07 ± 656.18	7910.78 ± 886.69

^⁎⁎

P < 0.01 versus Taxol.