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Representative MRM chromatograms of JDR, gemcitabine and didanosine (IS) in rat plasmas. (A1–A3): a blank rat plasma sample; (B1–B3): a blank rat plasma sample spiked with JDR (5 ng/ml), gemcitabine (4 ng/ml) and didanosine (750 ng/ml); (C1–C3): a rat plasma sample following an oral dose of JDR at 96 mg/kg (calculated as gemcitabine) to a Wister rat.
