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Pharmacokinetic parameters of JDR and gemcitabine in rat after oral administration JDR and gemcitabine (data were mean ± SD, n = 6).
| Ingredients | Cmax (ng/ml) | Tmax | AUC0-24 (mg ⋅ h /l) | T1/2 (h) |
|---|---|---|---|---|
| JDR-JDR | 4153.18 ± 1927.40 | 1.08 ± 0.9 | 12828.59 ± 2204.5 | 6.31 ± 3.9 |
| JDR-gemcitabine | 2658.04 ± 1212.6** | 1.00 ± 0.0 | 16132.95 ± 5128.0** | 6.36 ± 2.1** |
| Gemcitabine | 1181.17 ± 47.1 | 1.50 ± 0.9 | 5031.61 ± 627.4 | 2.61 ± 1.1 |
P < 0.01 compared with gemcitabine.
