Table 5.
Pharmacokinetic parameters of BBR preparations after single administration in dogs T represent BBR pellets, R represent BBR tablet.
| Single dose groups |
||||||
|---|---|---|---|---|---|---|
| Pharmacokinetic parameters | T-150 | R-150 | T-300 | R-300 | T-600 | R-600 |
| T1/2 (h) | 35.11 ± 6.32 | 26.97 ± 14.48 | 35.05 ± 10.28 | 20.02 ± 10.59 | 37.74 ± 12.33 | 24.52 ± 12.94 |
| Tmax (h) | 29.33 ± 9.35 | 15.33 ± 10.46 | 21.33 ± 10.01 | 13.83 ± 8.54 | 22.33 ± 13.54 | 18.33 ± 12.03 |
| Cmax (µg/l) | 0.45 ± 0.12 | 1.39 ± 0.54 | 1.04 ± 0.46 | 1.77 ± 0.91 | 1.97 ± 0.89 | 3.69 ± 1.14 |
| AUC0-t (µg/l·h) | 28.46 ± 8.34 | 40.30 ± 14.59 | 50.42 ± 20.61 | 72.93 ± 46.31 | 88.68 ± 27.77 | 118.74 ± 74.92 |
| AUC0-∞(µg/l·h) | 30.06 ± 9.31 | 41.29 ± 15.62 | 53.98 ± 21.65 | 77.68 ± 49.29 | 91.65 ± 30.23 | 126.43 ± 79.77 |
| MRT (h) | 39.23 ± 2.13 | 39.08 ± 11.20 | 36.68 ± 2.50 | 35.97 ± 3.69 | 36.28 ± 9.04 | 33.07 ± 4.65 |
| CL (L/h) | 10,415 ± 2123 | 3040 ± 850 | 7056 ± 3021 | 5977 ± 4657 | 6864 ± 2046 | 4251 ± 3970 |