Table 4.
The toxicity of NK-TUDCA (NK: 10 kIU/ml; pH 5.0) with different concentrations of TUDCA after a single intravenous injection of 130 kIU/kg NK (n = 3).
| Preparation (pH 5.0) | Injection dosage of TUDCA (mg/kg) | Death rate (%) | Survival time (min) | State |
|---|---|---|---|---|
| NK | 0 | 100 | 1, 1, 1 | ccc |
| NK-TUDCA (TUDCA: 1 mg/ml) | 13 | 100 | 2, 2, 4 | ccc |
| NK-TUDCA (TUDCA: 5 mg/ml) | 65 | 0 | a, a, a | bbb |
| NK-TUDCA (TUDCA: 10 mg/ml) | 130 | 0 | a, a, a | bbb |
| NK-TUDCA (TUDCA: 15 mg/ml) | 195 | 0 | a, a, a | bbb |
a
The mouse was not dead within 48 h after injection.
b
The mouse exhibited shortness of breath, sports reduction, and drowsiness.
c
The mouse exhibited symptoms of shortness of breath, tetany, bleeding from mouth and nose, and death.