Table 1.

Aqueous solubility of dutasteride complexed with various cyclodextrins at a 1:50 weight ratio and the average binding affinity as obtained by the computer docking simulation tool Glide (Schrödinger, New York, USA).

Cyclodextrin	Solubility ($\mu \mathrm{g}/\text{ml}$)*	Average binding affinity (ΔGbind) (kcal/mol)
α-cyclodextrin	1.3 ± 0.3	−55.14
β-cyclodextrin	23.8 ± 1.8	−89.58
γ-cyclodextrin	61.8 ± 3.1	−98.69
HP-β-cyclodextrin	25.5 ± 2.0	ND

ND: not determined.

^⁎Each value is the mean ± SD (n = 3).