Table 5.
Pharmacokinetic parameters of dutasteride after oral administration of the reference (Avodart®) or DuγCD-PS complex at a dose of 2.39 mg/kg of dutasteride in rats.
| Rx | Tmax (h) | Cmax (ng/ml) | AUC0-24h (ng·h/ml) | Relative BA% (to the reference) |
|---|---|---|---|---|
| Reference (Avodart®) | 10.4 ± 7.8 | 253.4 ± 22.8 | 4336.9 ± 497.4 | – |
| F1 | 12.0 ± 8.0 | 63.7 ± 23.5 | 1282.4 ± 334.9 | 29.6 |
| F2 | 8.9 ± 9.0 | 148.8 ± 31.9 | 3147.3 ± 689.1 | 72.6 |
| F3 | 10.4 ± 7.8 | 170.6 ± 43.4 | 3228.2 ± 459.9 | 74.4 |
| F4 | 3.0 ± 1.2 | 215.2 ± 51.3 | 4061.1 ± 588.9 | 93.6 |
| F5 | 11.0 ± 8.9 | 195.8 ± 21.3 | 4060.2 ± 295.3 | 93.6 |
Each value is the mean ± SD (n = 4–6).