Table 2.

Main pharmacokinetic parameters of BE and BA in plasma after oral BE (Mean ± SD, n = 6).

		BE coarse powder		BE-NCT cocrystals		BE nanocrystals		BE-NCT nano-cocrystals
Parameters	Unit	BE	BA	BE	BA	BE	BA	BE	BA
Cmax	ng/ml	63.81 ± 24.22	2917.29 ± 785.00	96.42 ± 39.04	4165.77 ± 386.23	86.72 ± 57.97	8044.62 ± 1265.57	156.86 ± 56.32	6728.56 ± 1260.12
Tmax1	h	0.92 ± 1.17	0.53 ± 0.54	0.78 ± 0.95	2.17 ± 2.93	0.37 ± 0.40	0.28 ± 0.19	0.90 ± 0.92	1.58 ± 0.98
Tmax2	h	5.17 ± 1.83	6.50 ± 2.66	10.67 ± 2.07	9.67 ± 2.66	8.33 ± 3.20	4.67 ± 1.97	11.67 ± 3.20	12.67 ± 2.73
AUC0−t	h·µg/ml	0.23 ± 0.10	17.95 ± 5.24	1.54 ± 0.22	52.32 ± 9.27	0.38 ± 0.19	59.21 ± 6.95	2.70 ± 0.56	109.34 ± 18.73
Lz	1/h	0.50 ± 0.41	0.28 ± 0.05	0.03 ± 0.01	0.11 ± 0.01	8.58 ± 6.31	0.14 ± 0.06	0.05 ± 0.01	0.14 ± 0.01
AUMC0−t	h·h·µg/ml	1.55 ± 1.32	147.17 ± 61.91	30.43 ± 3.16	637.42 ± 141.14	4.45 ± 2.36	563.17 ± 53.13	49.19 ± 10.57	1521.77 ± 509.50
T1/2	h	4.61 ± 6.25	2.49 ± 0.40	26.77 ± 7.76	6.29 ± 0.74	8.58 ± 6.31	6.10 ± 2.64	15.72 ± 4.34	4.93 ± 0.27
Vz/F	l/kg	1704.59 ± 1988.60	17.86 ± 8.53	1318.81 ± 355.02	14.13 ± 3.24	2485.51 ± 1774.77	12.08 ± 5.92	586.06 ± 242.25	5.37 ± 1.24
CL/F	l/h/kg	383.82 ± 190.68	4.83 ± 1.68	34.44 ± 2.80	1.56 ± 0.34	227.92 ± 91.53	1.35 ± 0.15	25.18 ± 3.56	0.75 ± 0.14
MRT	h	5.72 ± 2.53	7.88 ± 1.53	19.91 ± 1.14	12.15 ± 1.21	11.67 ± 4.95	9.58 ± 1.00	18.20 ± 1.10	13.64 ± 2.50