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AUC0 − t and AUC weighted factors (ω) of the BE and BA in rat plasma after oral administration of BE coarse powder, BE-NCT cocrystals, BE nanocrystals and BE-NCT nano-cocrystals (Mean ± SD, n = 6).
| BE coarse powder |
BE-NCT cocrystals |
BE nanocrystals |
BE-NCT nano-cocrystals |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameters | Unit | BE | BA | BE | BA | BE | BA | BE | BA |
| AUC0−t | h·µg/ml | 0.23 ± 0.10 | 17.95 ± 5.24 | 1.54 ± 0.22 | 52.32 ± 9.27 | 0.38 ± 0.19 | 59.21 ± 6.95 | 2.70 ± 0.56 | 109.34 ± 18.73 |
| ω | 0.01 | 0.99 | 0.03 | 0.97 | 0.01 | 0.99 | 0.02 | 0.98 | |
