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Pharmacokinetic parameters of AC in rats after oral administration of AC suspension and AC-PLGA-NPs at a dose of 5 mg/kg (mean + SD, n = 5).
| Preparations | t1/2 (h) | Cmax (ng/mL) | Tmax (h) | AUC (ng/mL*h) |
|---|---|---|---|---|
| AC suspension | 0.68 ± 0.29 | 49.37 ± 26.05 | 0.30 ± 0.14 | 45.32 ± 30.80 |
| AC-PLGA-NPs | 1.08 ± 0.34 | 183.81 ± 77.28** | 0.37 ± 0.14 | 214.04 ± 58.02*** |
