Table 2.
Composition of blend for SR matrix tablet prepared by various methods and its process parameters.
| Ingredients | Drug loading | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| F1 a | F2a | F3a | F4a | F5a | F6a | F7a | F8a | F9b | F10c | |
| Metformin HCl | 50 | 55 | 60 | 65 | 70 | 75 | 80 | 85 | 75 | 75 |
| HPC Nisso-H | 40 | 35 | 30 | 25 | 20 | 15 | 10 | 5 | 15 | 15 |
| Stearic acid | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| Purified water | – | – | – | – | – | – | – | – | – | q.s.d |
| Extrusion with die | + | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Extrusion without die | NA | + | + | + | + | + | + | + | NA | NA |
All quantities are in percentage (w/w).
a
Melt granulation with HPC Nisso-H.
b
Dry granulation with HPC Nisso-H.
c
Wet granulation with HPC Nisso-H.
d
Water used for granulation and removed by drying.