Table 5.

Properties of tablets produced by the melt granulation process with various drug loadings.

Formulation code	Tablet properties
	Weight (mg)a	Dimensions (L × B × T) (mm)b			Hardness (kN)b	Friability (%)b	Assay (%)b	Moisture contentb (%)
		L	B	T
F1	1015.8 ± 2.65	17.71 ± 0.01	9.51 ± 0.02	6.62 ± 0.01	16.53 ± 0.26	0.32 ± 0.31	97.22 ± 1.89	0.572 ± 0.06
F2	920.34 ± 2.46	16.84 ± 0.03	8.94 ± 0.02	7.23 ± 0.02	14.97 ± 0.58	0.38 ± 0.26	99.63 ± 0.61	0.688 ± 0.01
F3	844.17 ± 3.39	16.88 ± 0.01	9.07 ± 0.03	6.92 ± 0.02	15.08 ± 0.65	0.27 ± 0.21	98.93 ± 0.47	0.739 ± 0.02
F4	779.77 ± 3.47	16.90 ± 0.03	8.97 ± 0.02	5.99 ± 0.04	15.54 ± 0.36	0.39 ± 0.36	96.32 ± 1.12	0.489 ± 0.03
F5	732.06 ± 5.63	16.89 ± 0.03	8.96 ± 0.03	5.46 ± 0.02	16.42 ± 0.40	0.28 ± 0.18	97.38 ± 0.71	0.871 ± 0.07
F6	669.93 ± 2.48	16.91 ± 0.02	8.95 ± 0.05	5.20 ± 0.02	15.51 ± 0.39	0.23 ± 0.29	99.09 ± 1.07	0.792 ± 0.03
F7	635.15 ± 3.27	16.90 ± 0.02	8.99 ± 0.01	4.84 ± 0.04	14.48 ± 0.97	0.28 ± 0.21	98.93 ± 1.33	0.972 ± 0.05
F9	680.65 ± 7.79	16.96 ± 0.01	8.97 ± 0.01	5.24 ± 0.01	7.46 ± 0.28	1.85 ± 1.31	99.17 ± 1.58	1.894 ± 0.13
F10	679.41 ± 7.20	16.96 ± 0.01	9.02 ± 0.02	5.19 ± 0.02	12.95 ± 0.34	0.81 ± 1.14	97.23 ± 1.36	2.172 ± 0.31
Marketed tablet	753.80 ± 5.21	16.09 ± 0.03	8.10 ± 0.04	6.45 ± 0.02	14.02 ± 0.16	0.17 ± 0.11	97.31 ± 1.19	–

^a± Standard deviation, n = 20.

^b± Standard deviation, n = 10.