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Pharmacokinetic parameters following oral administration of AZL nanosuspension (Nano1) and physical mixture (mean ± SD, n = 6).
| Pharmacokinetic parameters | Physical mixture | Nanosuspension |
|---|---|---|
| Tmax (h) | 1.17 ± 0.65 | 0.79 ± 0.19 |
| Cmax (µg⋅ml−1) | 26.45 ± 8.01 | 56.50 ± 8.85 |
| T1/2 (h) | 11.62 ± 1.43 | 10.46 ± 2.51 |
| AUC0-72h (µg⋅h⋅ml−1) | 231.63 ± 72.50 | 545.49 ± 268.61 |
| AUC0-∞ (µg⋅h⋅ml−1) | 236.00 ± 71.19 | 555.46 ± 269.90 |
