Fig. 3.
Synthesis of amino acid amide prodrugs of peramivir (11a–g). (i) TEA, EDC, HOBt, amino acid methyl ester, DMF, room temperature, 24 h; (ii) LiOH, EtOH, THF and water, overnight, room temperature; (iii) TFA, CH2Cl2, room temperature, 16 h.
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