Figure S7. In vivo toxicity and efficacy of 5-FdU.

(A) Mouse body weights were tracked longitudinally throughout the indicated treatment regimens (n = 5). (B) Immunohistochemistry detection of γH2AX in lungs of mice treated with the indicated doses of 5-FdU. When micrometastatic foci were present, evidence of DNA damage and γH2AX staining is readily observed (arrowheads). Nonspecific anti-rabbit IgG serves as a negative control. Scale bar: 100 μm. ***P < 0.001, Kruskal–Wallis test.