| Methods |
Allocation: randomised ‐ computer generated.
Blindness: double‐blind ‐ no further details.
Duration: 6 weeks (> 1 day washout). |
| Participants |
Diagnosis: schizophrenia (DSM‐III‐R).
Inclusion criteria: BPRS* >/=27, CGI >/=4.
N=286.
Age: mean ˜37 years.
Sex: M 203, F 83. |
| Interventions |
1. Quetiapine: mean dose 360 mg/day. N=96.
2. Quetiapine: mean dose 209 mg/day. N=94.
3. Placebo: N=96. |
| Outcomes |
Global state: CGI.
Mental state: BPRS, BPRS positive, SANS, PANSS‐N.
Adverse effects: AIMS, Barnes Akathisia Scale, SAS, specific side‐effects list.
Leaving the study early. |
| Notes |
* 0‐6 scoring system. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
