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. 1999 Jul 26;1999(3):CD001164. doi: 10.1002/14651858.CD001164

Ahlfors 1980.

Methods Allocation: randomised, no further information. 
 Blindness: double ‐ drugs given by a nurse not involved in trial. 
 Setting: hospital, multi‐centre. 
 Rating: reliablity study undertaken. 
 Duration: 6 months ‐ preceeded by 1‐4 week wash‐out period.
Participants Diagnosis: schizophrenia (Bleuler criteria). 
 N=172. 
 Sex: 114 M, 58 F. 
 Age: 20‐65 years. 
 Inclusion: 2+ years ill & poor response to present drugs or admitted for exacerbation of illness. 
 Exclusion: somatic disease, pregnancy, drug or alcohol misuse, >65yrs.
Interventions 1. Zuclopenthixol decanoate: dose mean 280mg/IM, range 50‐800 mg/IM. N=87. 
 2. Perphenazine enanthate: dose mean 141 mg/IM, range 20‐600 mg/IM. N=85. 
 Dose interval: 2/52. 
 Other medications allowed: nitrazepam or chloral hydrate, amitryptiline, diazepam, biperiden.
Outcomes Death. 
 Global Impression (CGI). 
 Relapse. 
 Leaving the study early. 
 Additional medication. 
 Side effects (EPS).
Unable to use ‐ 
 Mental state (BPRS ‐ no SD, scores given as residual %). 
 Behaviour (NOSIE‐36 ‐ no SD). 
 Lab tests (no data).
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear