Ahlfors 1980.
Methods | Allocation: randomised, no further information. Blindness: double ‐ drugs given by a nurse not involved in trial. Setting: hospital, multi‐centre. Rating: reliablity study undertaken. Duration: 6 months ‐ preceeded by 1‐4 week wash‐out period. | |
Participants | Diagnosis: schizophrenia (Bleuler criteria). N=172. Sex: 114 M, 58 F. Age: 20‐65 years. Inclusion: 2+ years ill & poor response to present drugs or admitted for exacerbation of illness. Exclusion: somatic disease, pregnancy, drug or alcohol misuse, >65yrs. | |
Interventions | 1. Zuclopenthixol decanoate: dose mean 280mg/IM, range 50‐800 mg/IM. N=87. 2. Perphenazine enanthate: dose mean 141 mg/IM, range 20‐600 mg/IM. N=85. Dose interval: 2/52. Other medications allowed: nitrazepam or chloral hydrate, amitryptiline, diazepam, biperiden. | |
Outcomes | Death.
Global Impression (CGI).
Relapse.
Leaving the study early.
Additional medication.
Side effects (EPS). Unable to use ‐ Mental state (BPRS ‐ no SD, scores given as residual %). Behaviour (NOSIE‐36 ‐ no SD). Lab tests (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |