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. 2019 Oct 8;22(2):253–266. doi: 10.1093/neuonc/noz189

Fig. 3.

Fig. 3.

CCL5 induces PYK2 phosphorylation and MMP2 activation in glioma cells. (A) PYK2 phosphorylation in A172 and U87 cells was induced by CCL5 (10 ng/mL) in a time-dependent manner. (B) CCL5 (0–10 ng/mL) induced a concentration-dependent increase in PYK2 phosphorylation in A172 and U87 cells. (C) MMP2 protease activity and protein expression were induced by 24 h of CCL5 treatment (10 ng/mL) in both A172 and U87 cells. (D) CCL5 (0–10 ng/mL) induced an increase in PYK2 phosphorylation and cleaved MMP2 expression in W802 cells. Blots are quantified as fold of control.