Mickleborough 2001.
Methods | Randomised placebo‐controlled cross‐over study. | |
Participants | 16 participants. 8 participants with exercise‐induced asthma (mean age 22 years and all using short beta agonists) and 8 controls (mean age 23 years). The population was recruited from a university population. Exclusion criteria: none of the participants had atopic asthma. |
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Interventions | All participants entered the study on a normal sodium diet and were started a low sodium diet (65 mmol of sodium using a meal plan). All participants were randomised to a low sodium limb (placebo tablets) or high sodium low chloride limb (174 mmol of sodium a day as sodium bicarbonate) for 2 weeks. After this a 1‐week wash‐out period followed and then participants switched to the alternative diet. | |
Outcomes | FEV1,FVC, FEV1/FVC pre‐exercise and post‐exercise measurement at 1, 5, 10 and 15 minutes. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Independent investigator had no contact with the subjects and no involvement in data collection or analysis used a computerised random number generator to create the randomisation sequence. |
Allocation concealment (selection bias) | Low risk | Randomised study with independent investigator generating the sequence. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Described as blinded; no other information available. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | |
Selective reporting (reporting bias) | Unclear risk | Not clear from information given. |
Other bias | Unclear risk | Participants recruited from a university population. No calculation of power. |