Comparison 1. Hypericum mono‐preparations vs. placebo A. Dichotomous measures.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Responder ‐ grouped by precision ‐ primary analysis	18	3064	Risk Ratio (M‐H, Random, 95% CI)	1.48 [1.23, 1.77]
1.1 Less precise trials	9	1020	Risk Ratio (M‐H, Random, 95% CI)	1.87 [1.22, 2.87]
1.2 More precise trials	9	2044	Risk Ratio (M‐H, Random, 95% CI)	1.28 [1.10, 1.49]
2 Responder ‐ according to HAMD	16	2706	Risk Ratio (M‐H, Random, 95% CI)	1.51 [1.22, 1.87]
2.1 Less precise trials	8	948	Risk Ratio (M‐H, Random, 95% CI)	1.94 [1.19, 3.18]
2.2 More precise trials	8	1758	Risk Ratio (M‐H, Random, 95% CI)	1.28 [1.06, 1.53]
3 Responder ‐ according to CGI (Clinical Global Impression Index at least "much improved")	13	2306	Risk Ratio (M‐H, Random, 95% CI)	1.47 [1.24, 1.74]
3.1 Less precise trials	7	869	Risk Ratio (M‐H, Random, 95% CI)	1.74 [1.30, 2.33]
3.2 More precise trials	6	1437	Risk Ratio (M‐H, Random, 95% CI)	1.26 [1.06, 1.50]
4 Responder ‐ grouped by extract	18		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 extract LI 160	6	981	Risk Ratio (M‐H, Random, 95% CI)	1.31 [0.92, 1.86]
4.2 extract WS 5570	2	699	Risk Ratio (M‐H, Random, 95% CI)	1.57 [0.96, 2.56]
4.3 extract WS 5572	2	170	Risk Ratio (M‐H, Random, 95% CI)	1.47 [1.05, 2.06]
4.4 extract STW3‐VI	2	401	Risk Ratio (M‐H, Random, 95% CI)	3.59 [0.41, 31.56]
4.5 other extracts	6	813	Risk Ratio (M‐H, Random, 95% CI)	1.45 [1.08, 1.93]
5 Responder among studies from German‐speaking countries and other studies	18	3064	Risk Ratio (M‐H, Random, 95% CI)	1.48 [1.23, 1.77]
5.1 Studies from German‐speaking countries	11	1770	Risk Ratio (M‐H, Random, 95% CI)	1.78 [1.42, 2.25]
5.2 Studies from other countries	7	1294	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.88, 1.31]
6 Remission (HAMD score < 8 or < 7)	6	1236	Odds Ratio (M‐H, Random, 95% CI)	2.77 [1.80, 4.26]