| Methods |
Concealment: unclear
Blinding: Double‐blind (double dummy)
Drop‐outs/withdrawals: 15/157 (hypericum), 32 of 167 (imipramine)
Jadad score: 2‐2‐0
IV score: 1‐0‐1‐0.5‐0.5‐0 |
| Participants |
Patients included/analyzed: 324/324
Demographics: 71% female, mean age 46 years
Diagnosis: mild to moderate depression (ICD10 F32.0 or 1, F33.0 or 1)
Setting: 40 practices for psychiatry, internal medicine, GP in Germany
Baseline: HAMD 22.4 +/‐3.4 (hypericum), 22.1 +/‐ 2.9 (imipramine) |
| Interventions |
Treatment: 2x1 coated tablet (500 mg extract) Hypericum extract ZE 117 daily for 6 weeks
Control: Imipramine 150 mg daily for 6 weeks |
| Outcomes |
Observation period: 6 weeks
Physician‐rated: Hamilton Depression Scale (HAMD, 17 items; at least 50% reduction), Clinical Global Impression Index (CGI)
Patient‐rated: global assessment |
| Notes |
Some additional information by manufacturer of the extract |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
