Study	Reason for exclusion
Agrawal 1994	Not major depression (Study in patients with fatigue and minor depression)
Albertini 1986	Not depression (RCT of hypericum in homeopathic preparation for dental neuralgia)
Bendre 1980	Not depression (CCT of homeopathic preparations of hypericum and arnica in dental practice)
Bergmann 1993	Inadequate dosage of amitriptyline (30 mg daily) ‐ RCT included in previous versions of this review
Bernhadt 1993	RCT comparing two doses of hypericum for depression
Brockmöller 1997	RCT on pharmacokinetics and photosensitivity in healthy volunteers
Czekalla 1997	Report of results on ECG analyses undertaken in the Vorbach 1997 study
Dittmer 1992	Only a minority of patients suffered from depression (RCT of Hypericum for "psychovegetative complaints")
Ditzler 1992	Placebo‐controlled randomized controlled trial in depressed patients using a fixed combination of several herbs including hypericum
Gu 2001	RCT comparing 900 mg of a hypericum extract with fluoxetine in patients with depression according to the Chinese classification CCMD‐2. As it is not clear whether all included patients meet criteria for major depression the study was excluded. Response rates were similar in both groups
Halama 1991	Not major depression (placebo‐controlled trial included in previous versions of the review)
Harrer 1991	Not major depression (placebo‐controlled trial included in previous versions of the review)
Herberg 1992	RCT comparing hypericum and a combination of Hypericum and Valerian on concentration, reaction etc. in healthy volunteers
Hoffmann 1979	Not major depression (placebo‐controlled trial included in previous versions of the review)
Hottenrott 1997	Not depression (RCT of a combination of hypericum and vitamine E to enhance performance of athlets)
Häring 1996	Placebo‐controlled RCT of hypericum to prevent reactive depression in 28 patients with solid tumors undergoing chemotherapy
Hübner 1993	Not major depression (placebo‐controlled trial included in previous versions of the review)
Johnson 1992	RCT on neurophysiological effects of hypericum in healthy volunteers
Johnson 1993	RCT comparing neurophysiological effects of hypericum and maprotiline in healthy volunteers
Kniebel 1988	RCT comparing a combination of hypericum and valerian vs. amitriptyline in depressive patients
Kugler 1990a	RCT comparing hypericum and bromazepam in depressed patients (included in earlier versions of this review; inclusion has now been limited to commonly recommended standard antidepressants)
Kugler 1990b	RCT on pharmacodynamics in depressed patients (reason for exclusion: no symptomatic outcomes related to depressive symptoms)
König 1993	Not major depression (placebo‐controlled trial included in previous versions of the review)
Lehrl 1993	Diagnosis not decscribed as major depression in publication. An information collected from the sponsor for a previous version of the review that patients met criteria for major depression could not be verified (placebo‐controlled trial included in previous versions of the review)
Lenoir 1999	RCT comparing three dosages of a hypericum extract in depressive patients
Li 2005	Not major depression (placebo‐controlled RCT in depressive patients undergoing coronary artery bypass grafting)
Maisenbacher 1995	Not all patients suffered from depression (RCT of hypericum for anxiety)
Martinez 1993	RCT comparing light therapy and a combination of light therapy and hypericum in patients with seasonal affective disorder
Mo 2004	Not major depression (RCT comparing an hypericum extract and fluoxetine in post‐stroke depression)
Osterheider 1992	Not major depression (placebo‐controlled trial included in previous versions of the review)
Panijel 1985	Not depression (RCT of a combination of hypericum and valerian for anxiety)
Quandt 1993	Not major depression (placebo‐controlled trial included in previous versions of the review)
Reh 1992	Not major depression (placebo‐controlled trial included in previous versions of the review)
Schlich 1987	Not major depression (placebo‐controlled trial included in previous versions of the review)
Schmidt 1989	Not major depression (placebo‐controlled trial included in previous versions of the review)
Schmidt 1993	Not major depression (placebo‐controlled trial included in previous versions of the review)
Schmidt 1993b	RCT investigating possible interactions of hypericum and alcohol in healthy volunteers
Schulz 1993	RCT investigating the effects of hypericum on the sleep‐EEG in elderly volunteers
Sindrup 2000	RCT in patients with polyneuropathy (depression not mentioned)
Sommer 1994	Not major depression (placebo‐controlled trial included in previous versions of the review)
Spielberger 1985	RCT comparing two hypericum preparations for depression
Staffeldt 1993	RCT on pharmacokinetics in healthy volunteers
Steger 1985	RCT of a comination of of hypericum and valerian vs. desipramine for depression
Volz 2002	RCT hypreicum vs. placebo in patients with somatoform disorders
Vorbach 1994	Not all patients met criteria for major depression (comparison with maprotiline; included in previous versions of the review)
Warnecke 1986	Open controlled trial of hypericum vs. diazepam in women with climacteric depression; method of allocation unclear (included in earlier version of this review; now inclusion limited to explicitely randomized, double‐blind trials)
Werth 1989	RCT of hypericum vs. amitriptyline for about two weeks in patients undergoing amputation to prevent reactive depression (included in earlier version of this review)
Wienert 1991	RCT on photosensitivtity after application of a combination of hypericum and valerian
Winkel 2000	Not major depression (placebo‐controlled trial included in previous versions of the review)
Zeller 2000	(Nonrandomized?) comparison of different administration schedules of a hypericum extract in patients with mild to moderate depression (not restricted to major depression)