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. 2003 Apr 22;2003(2):CD000440. doi: 10.1002/14651858.CD000440

Emsley 1995.

Methods Allocation: randomised (no further description). 
 Blindness: double (no further description). 
 Duration: 6 weeks. 
 Consent: not stated. 
 Setting: multicentre, multinational.
Participants Diagnosis:schizophrenia or schizophreniform disorder (DSM‐III‐R). 
 N=183. 
 Sex: 122M, 61F. 
 Age: 15‐50 years. 
 History: first‐episode. 
 Exclusions: not stated
Interventions 1. Risperidone: 2‐16 mg/day, an initial dose of 4mg/day was adjusted as required throughout the trial. N=99. 
 2. Haloperidol: 1‐16 mg/day, an initial dose of 4mg/day was adjusted as required throughout the trial. N=84.
Outcomes Clinical improvement: >50% in PANSS. 
 Adverse effects: various observed effects. 
 Leaving the study early.
Unable to use ‐ 
 Global effect: CGI score (no SD). 
 Mental state BPRS ‐ PANSS derived, PANSS (no SD). 
 Physiological monitoring: ECG, lab tests (no data) 
 Adverse effects: ESRS (no SD).
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear