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. 2003 Apr 22;2003(2):CD000440. doi: 10.1002/14651858.CD000440

Huttunen 1995.

Methods Allocation: randomised (no further description). 
 Blindness: double (no further description). 
 Duration: 6 weeks. 
 Consent: given. 
 Setting: multicentre.
Participants Diagnosis: schizophrenia (DSM‐III‐R). 
 N=98. 
 Sex: 47M, 51F. 
 Age: 11‐43 years, mean ˜ 36 years. 
 History: chronic, currently acutely ill.
Interventions 1. Risperidone: 2‐20 mg/day, dose decided by clincial judgement. N=48. 
 2. Zuclopenthixol: 10‐100mg/day, dose decided by clincial judgement. N=50.
Outcomes Clinical improvement: 20% reduction in PANSS. 
 Comparison with previous medication: Categorical scale. 
 Adverse effects: use of antiparkinson medication, other various observed effects. 
 Leaving the study early.
Unable to use ‐ 
 Global effect: CGI (no SD). 
 Mental state: PANSS, BPRS ‐ PANSS derived (no SD). 
 Physiological monitoring: ECG, lab tests (no data). 
 Adverse effects: ESRS, UKU (no SD).
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear