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. 2003 Apr 22;2003(2):CD000440. doi: 10.1002/14651858.CD000440

See 1999.

Methods Allocation: randomised (no further description). 
 Blindness: double (no further description). 
 Duration: 5 weeks (preceeded by 3 weeks prestudy stablisation with trifluoperazine 20‐30 mg/day. This was reduced to 5‐10mg/day during week 1 and discontinued during week 2). 
 Consent: given. 
 Setting: hospital.
Participants Diagnosis: schizophrenia (DSM‐IV). 
 N=20. 
 Age: >18 years. 
 Sex: 14M, 6F. 
 History: chronic, partial responders to neuroleptics, residual sypmptoms. 
 Exclusions: not stated.
Interventions 1. Risperidone: 4‐6 mg/day. N=10. 
 2. Haloperidol: 15‐30 mg/day. N=10.
Benztropine mesylate as required.
Outcomes Mental state: PANSS. 
 Adverse effects: SAS. 
 Leaving the study early.*
Notes * Not stated, assumed to be zero.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear