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. 2020 Feb 7;14(2):e0008054. doi: 10.1371/journal.pntd.0008054

Fig 5. Evaluation of the ability of FNAV to neutralize CTX-induced necrosis.

Fig 5

(A) Different volumes of FNAV (0–40 μl) were pre-incubated with a fixed amount of CTXs (1.5 MND), and then intradermally injected into mice. The sizes of necrotic lesions in the dorsal skin of injected mice were measured. (B) Average size of necrotic lesions (n = 3) after neutralization by different volumes of FNAV. One-way ANOVA followed by Tukey’s multiple comparison test was performed to analyze differences. (C) The sizes of necrotic lesions were recorded after mice had been administered two additional batches of FNAV (40 μl). Positive controls were injected with 1.5 MND of CTXs, and negative controls received the same volume of PBS. (D) Necrosis-inducing ability presented as the size of necrotic lesions compared with that of positive controls. Each bar represents means ± SD of triplicates (ns: not significant; two sample t-test).