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Comparison of the activation free energies determined by EVB simulations (blue) and from experimental kinetic parameters (based on experimental kinetic measurements performed on TbbTIM, yTIM, and PfTIM,16,40−44,70 tan), for TIM-catalyzed deprotonation of substrates (A) DHAP and (B) GAP to form enediolate reaction intermediates. The raw data for this figure are presented in Table 1.
