Comparison 1. Prostacyclin analogues.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Iloprost vs. Placebo	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 patient global assessment of improvement (# improved)	1	63	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.55 [0.96, 6.80]
1.2 number of digital ulcers healed	1	11	Peto Odds Ratio (Peto, Fixed, 95% CI)	23.17 [2.20, 243.52]
1.3 side effects	3	229	Peto Odds Ratio (Peto, Fixed, 95% CI)	9.23 [5.29, 16.11]
1.4 physician global assessment (# improved)	1	122	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.61 [1.27, 5.38]
2 Cisaprost 2.5 ug vs. Placebo	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2.1 global assessment of improvement (# improved)	1	32	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.28 [0.33, 5.00]
2.2 side effects	1	32	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.76 [0.40, 7.65]