Cadranel 1986.

Methods	A randomized double‐blind placebo‐controlled clinical trial Efficacy Parallel design
Participants	N= 27 with PSS, 22 female and 5 male N= 13 patients in the Ketanserin group and N=14 patients in the placebo group Source of population: Community Country: France. No patients dropped out.
Interventions	Ketanserin or placebo for 6 months
Outcomes	Patients reports of arthralgias, dyspnea, and intensity of Raynaud's phenomenon Number of acral ulcers Skin scores Hand mobility Oral aperture Number and duration of RP attacks Total blood viscosity Plasma viscosity Thixotropism
Notes	Quality Score = 4