Dormandy 1988.

Methods	Double blind Parallel Placebo controlled Randomized
Participants	N=29 patients with typical symptoms and signs of RP for at least 1 year. 10 normal healthy volunteers in addition to 29 afflicted patients. No patients dropped out.
Interventions	1 week placebo run‐in period. Patients allocated to recieve either placebo or ketanserin for 4 weeks. Before any measurements patients and volunteers rested and avoided drinking and smoking.
Outcomes	At the start of the trial and after 4 weeks of double blind treatment digital blood flows were recorded. In the normal volunteers only one set of measurements was made. At the begining of the study patients were asked to keep a diary of duration and frequency of attacks throughout the trial. Assessment of the occurrence of cold sensation, numbness and pain were recorded.
Notes	Quality Score = 3