Lukac 1985.

Methods	A randomized double‐blind placebo‐controlled clinical trial Parallel design
Participants	N=15, 13 female and 2 male N= 8 in the Ketanserin group and N=7 in the placebo group Mean age = 51.1 yrs Source of Population: Community Country: Czechoslovakia. 1 patient dropped out.
Interventions	Oral Ketanserin or placebo 20mg TID for 1st month Oral Ketanserin or placebo 40mg TID for 2nd and 3rd months
Outcomes	Infrared radiometry for circulatiory damage U/S doppler for circulatory damage Capillary microscopy for circulatory damage Hand temperature Circulatory defects by ring thermographic index in std conditions and after cold stress Velocity of blood flow Number and extent of acral ulcerations BP Heart frequency Body weight Patient complaints ESR, CBC, plasma electrophoresis, AST, ALT, ANA, C3, latex fixation test Measurements taken at baseline and 3 months Duration: 3 months
Notes	Qualtiy Score = 3