TABLE I.
Shear stress regulated pathways.
| Class | Protein | Activation | Response |
|---|---|---|---|
| Receptors | GPCR68 | PS activated | Flow mediated dilation |
| PXR | PS activated | Antiinflammatory | |
| FLK-1 | OS activated | Inflammation | |
| JNK | OS activated | Apoptosis | |
| ERK | PS activated | Increased NO bioavailability | |
| Kinases | FAK | OS activated | Inflammation |
| AMPK | PS activated | Mitochondrial function | |
| AKT/PI3K | PS activated | Apoptosis | |
| CDK | PS activated | Antiproliferation | |
| MAPK | PS activated | Transcriptional regulation | |
| Junctional proteins | VE-cadherin | PS activated | Junction formation |
| Ion channels | Piezo1 | PS activated | Cellular development |
| E-selectin | PS inhibited | Inflammation | |
| Adhesion molecules | ICAM-1 | OS activated | Inflammation |
| VCAM-1 | OS activated | Inflammation | |
| MCP-1 | OS activated | Monocyte adhesion | |
| TIFA | OS activated | Inflammation | |
| Adaptor proteins | YAP/TAZ | OS activated | Proliferation and Inflammation |
| Paxillin | OS activated | Cell orientation | |
| KLF2/4 | PS activated | Flow mediated dilation | |
| Transcription factors | NFκB | OS activated | Inflammation |
| SMAD | OS activated | Proliferation | |
| Deacetylases | SIRT1 | PS activated | Increased NO bioavailability |
| Lipid metabolism | SREBP1/2 | OS activated | LDL binding |
| Membrane dynamics | Caveolin-1 | PS activated | Increased NO bioavailability |
| Small GTPases | Cdc42 | PS activated | Cell alignment |
| Ubiquitination | CBL | OS activated | Neonatal hyperplasia |