Figure 2.

Digestion of perineuronal nets (PNNs) in the insula does not affect sucrose or quinine drinking. A, Experimental design. Mice were injected with either chondroitinase ABC (ChABC) or phosphate buffered saline (PBS) in the insula on day 1, recovered for 2 days, and then were divided into 2 groups (n=6 per group) and given a two-bottle choice for 24 hours between a 2% sucrose solution vs. water or a 100 μM quinine solution vs. water. B, Quinine solution consumed, in ml per kg body weight. C, Percent quinine preference, calculated as volume of quinine solution consumed divided by volume of total fluid consumed. D, Water consumed, in ml per kg body weight during the quinine test. E, Sucrose solution consumed, in g sucrose per kg body weight. F, Percent sucrose preference, calculated as volume of sucrose solution consumed divided by volume of total fluid consumed. G, Water consumed (ml per kg body weight) during the sucrose test. Data are plotted as the mean ± SEM.