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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Immunol. 2020 Jan 27;204(5):1091–1100. doi: 10.4049/jimmunol.1900501

FIGURE 7.

FIGURE 7.

Blocking DNA repair of attempted CSR does not significantly alter the course of SLE-like disease in BXSB mice. (A-E) 6 week old BXSB males received either 50mg/Kg DIDS (n=4) or vehicle (K+, potassium bicarbonate, n=4) weekly for 8 injections. Mice were euthanized one week after final injection. Splenocytes were analyzed using flow cytometry and data are representative for 3 independent experiments. (A) Percentage of lymphocyte populations (B) Percentages of B cell populations (gating strategy the same as in Fig 4). (C) Percentage of germinal center B cells (D) Percentage of Tfh cells (E) Percentage of monocytes (F-H) 50mg/Kg DIDS (n=7) or vehicle (n=8) treated mice were analyzed. (G) Immunoglobulin isotypes in sera. (F) Mean intensity of ANA staining for pan Ig and IgG isotypes. Glomerular scores were evaluated in (H). Data are presented as mean±SEM. Statistical significance was determined by Mann-Whitney U test. *p<0.05.