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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Immunol. 2020 Jan 17;204(5):1334–1344. doi: 10.4049/jimmunol.1900650

Figure 1. Long-range chromatin interactions at the IL1 region.

Figure 1.

Primary monocytes were mock treated (blue) or treated with 1μg/ml LPS (red) for 30 minutes. A) Promoter contacts from IL1A, IL1B, IL37, IL1RN were analyzed by Capture-C in five separate biological replicates. Interactions were designated based on the geometric mean of the replicates. B) ATAC-Seq signal profile across the IL1A, IL1B, and IL37. This was performed on the same cells. C) H3K27ac, H3K4me1 and H3K4me3 peaks from primary monocytes treated with or without LPS for 1 hour. The ChIP-seq data were extracted from a published study (80). D) The long-range chromatin contacts defined by Capture-C and eRNA locations are displayed as an expanded view for IL1A, IL1B, and IL37.