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Percent of pregnancy mononuclear cells activated in response to treatment with L. iners or L. iners plus inhibitors of PAR-1 or ROCK. Inhibition of PAR-1 or ROCK prevented L. iners from causing nuclear translocation of TET2 and p65 and increasing IL-8 concentrations. (n = 7, mean ± SE, ****P < 0.0001)
