Fig. 4.
Role of NaV1.8 in INaL generation. Values are reported as mean ± SEM. One-way ANOVA with Tukey's test for multiple comparisons was used to calculate P values. a Original traces of INaL in human atrial cardiomyocytes and (b) mean data of INaL (integral 100–500 ms) showing the effects of NaV1.8 inhibition with either A-803467 (n = 12 cardiomyocytes/4 patients) or PF-01247324 (n = 10/4) on INaL compared to control (n = 15/6). c Original INaL traces representing INaL in SCN10A−/− mice as well as (d) WT and INaL after NaV1.8 inhibition by PF-01247324 and tetrodotoxin treatment respectively. e Mean values of INaL (integral 100–500 ms) showing the effects of genetic ablation of NaV1.8 (SCN10A−/−: n = 11 cells/5 mice) compared to WT (n = 8 cells/4 mice) and effects of pharmacological inhibition of NaV1.8 by PF-01247324 (SCN10A−/−: n = 7 cells/5 mice and WT: n = 7/4) and TTX (SCN10A−/−: n = 8 cells/5 mice and WT: n = 7/4) in each genotype