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. 2020 Feb 20;115(2):20. doi: 10.1007/s00395-020-0780-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Relevance of Na_V1.8 for diastolic sarcoplasmic Ca²⁺ leak. Values are given as mean ± SEM. One-way ANOVA with Tukey's test for multiple comparisons was used to calculate P values. a Representative confocal line scan images of human atrial cardiomyocytes loaded with the Ca²⁺ indicator Fluo-4 showing Ca²⁺ sparks during diastole. b Mean values of the frequency of Ca²⁺ sparks (CaSpF) and (c) the total calculated diastolic Ca²⁺ leak in atrial cardiomyocytes (n = 84 cardiomyocytes/13 patients) and after blocking Na_V1.8 with A-803467 (n = 73/9) or PF-01247324 (n = 88/11). d Original line scan images of murine atrial cardiomyocytes from SCN10A^−/− and (e) WT mice. f Mean values of CaSpF and (g) the total calculated diastolic Ca²⁺ leak in SCN10A^−/− (n = 57 cells/7 mice) and WT (n = 57 cells/7 mice) mice and, respectively, effects of Na_V1.8 inhibition by PF-01247324 (SCN10A^−/−: n = 57 cells/7 mice and WT: n = 62/7) and TTX (SCN10A^−/−: n = 64 cells/7 mice and WT: n = 61/7)