Table 1.
Statistically significantly different metabolites and their ratios between samples obtained from plaque psoriasis lesional (PS-L) and non-lesional (PS-NL) skin and the skin of healthy controls. Values are given in micromolar (μM) concentrations.
| Metabolite | Healthy controls mean (µM) | PS-L mean (µM) | PS-NL mean (µM) | KW p-value FDR 5% corrected |
|---|---|---|---|---|
| Amino acids | ||||
| Glu | 139.444 | 342.85 | 139.52 | 0.0001 |
| Met | 7.828 | 20.142 | 7.852 | 0.0002 |
| Arg | 49.728 | 136.455 | 60.55 | 0.0042 |
| Lys | 50.179 | 83.16 | 38.261 | 0.0063 |
| Leu | 50.924 | 90.3 | 31.96 | 0.0079 |
| Met.SO | 1.559 | 1.255 | 0.435 | 0.0323 |
| Phe | 31.434 | 49.705 | 22.78 | 0.0329 |
| Dimethylarginines | ||||
| ADMA | 0.571 | 1.419 | 0.475 | 0.0002 |
| total.DMA | 0.068 | 0.519 | 0.034 | 0.0002 |
| Biogenic amines | ||||
| Spermidine | 1.782 | 6.234 | 4.178 | < 0.0001 |
| Putrescine | 0.889 | 2.383 | 1.31 | 0.0002 |
| Histamine | ||||
| Histamine | 11.195 | 21.197 | 14.976 | 0.0138 |
| Carnitines | ||||
| C5 | 0.359 | 1.52 | 0.372 | < 0.0001 |
| C2 | 3.636 | 4.32 | 3.041 | 0.0063 |
| C18.2 | 0.026 | 0.041 | 0.025 | 0.0063 |
| C16 | 0.066 | 0.096 | 0.061 | 0.02 |
| C18.1 | 0.059 | 0.075 | 0.044 | 0.0207 |
| C18 | 1.589 | 3.265 | 1.93 | 0.0368 |
| Metabolite ratios | ||||
| Cit…Orn | 4.914 | 2.526 | 8.168 | 0.0018 |
| Orn…Arg | 0.763 | 0.193 | 0.378 | 0.0048 |
| Fisher.ratio | 1.847 | 2.025 | 1.698 | 0.0237 |
| X.C2.C3….C0 | 0.35 | 0.306 | 0.289 | 0.0339 |
| Glycerophospholipids | ||||
| PC.ae.C36.0 | 0.364 | 1.643 | 0.358 | 0.0003 |
| lysoPC.a.C16.1 | 0.585 | 0.76 | 0.335 | 0.0064 |
| PC.ae.C38.0 | 0.196 | 0.392 | 0.189 | 0.0125 |
| PC.ae.C34.0 | 0.402 | 0.85 | 0.4 | 0.0244 |
| PC.aa.C42.4 | 0.024 | 0.038 | 0.02 | 0.0248 |
| PC.ae.C38.1 | 0.177 | 0.423 | 0.219 | 0.0323 |
| PC.aa.C40.4 | 0.233 | 0.37 | 0.239 | 0.0386 |