Table 3.
Diagnostic test characteristics of sST2 for diagnosis of acute aortic syndromes.
| Variable | Case adjudication | sST2 ≥ 12 ng/mLA | sST2 ≥ 23.7 ng/mLB | sST2 ≥ 66.5 ng/mLC |
|---|---|---|---|---|
| Sensitivity (%) | CTA (n = 162) and diagnostic outcome (n = 297) | 95.5% (95%CI 88.8–98.7%) | 84.1% (95%CI 74.8–91%) | 35.2% (95%CI 25.3–46.1%) |
| Specificity (%) | CTA (n = 162) | 10.8% (95%CI 4.8–20.2%) | 29.7% (95%CI 19.7–41.5%) | 85.1% (95%CI 75–92.3%) |
| diagnostic outcome (n = 297) | 8.6% (95%CI 5.2–13.3%) | 35.4% (95%CI 28.9–42.3%) | 89.5% (95%CI 84.5–93.3%) | |
| LR+ | CTA (n = 162) | 1.07 (95%CI 1–1.2) | 1.20 (95%CI 1–1.4) | 2.37 (95%CI 1.3–4.4) |
| diagnostic outcome (n = 297) | 1.04 (95%CI 1.0–1.1) | 1.3 (95%CI 1.1–1.5) | 3.35 (95%CI 2.1–5.4) | |
| LR− | CTA (n = 162) | 0.42 (95%CI 0.1–1.3) | 0.54 (95%CI 0.3–1) | 0.76 (95%CI 0.6–0.9) |
| diagnostic outcome (n = 297) | 0.53 (95%CI 0.2–1.5) | 0.45 (95%CI 0.3–0.8) | 0.72 (95%CI 0.6–0.9) |
ACutoff providing similar sensitivity to D-dimer (cutoff 500 ng/mL) in the CTA-based analysis; Bcutoff providing similar specificity to D-dimer (cutoff 500 ng/mL) in the CTA-based analysis; Ccutoff maximizing sensitivity and specificity (Youden’s method) in the CTA-based analysis. LR: likelihood ratio.