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. 2020 Feb 20;11:973. doi: 10.1038/s41467-020-14794-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Complete GDP-Fuc and G0 binding sites of the HsFUT8-GDP-G0 complex. The residues forming the GDP-Fuc/A^G0/B^G0 and C^G0/D^G0/E^G0/F^G0/G^G0 binding sites are depicted as gray and aquamarine/orange carbon atoms, respectively. GDP, G0 and glycerol are shown as orange, green and blue carbon atoms, respectively. Hydrogen bond interactions are shown as dotted black lines. b, c Close-up view of the binding site region of the HsFUT8-GDP-G0 and HsFUT8-GDP-Fuc-G0 complexes showing the essential residues (Arg365, Lys369 and Glu373) that are major players in the plausible S_N2 single-displacement reaction mechanism. Note the proximity and the orientation of the A^G0 OH6 to the anomeric carbon (4.48 Å) which is compatible with the inversion of the configuration during the reaction.