Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;11:983. doi: 10.1038/s41467-020-14527-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Schematic showing desorption of PEG-lipids from LNPs allows ApoE binding causing LDL-mediated cellular uptake in cells following which a small portion of nucleic acids escape the endosome and the majority are recycled back by lysosomal transporters or directed to degradative endocytic compartments. b IUPAC-IUB nomenclature of (1989) cholesterol ring system with rings (A, B, C, and D), carbon numbering from C-1 to C-29, c the structure of cholesterol, and d schematic diagram showing classification of cholesterol into three regions: head, body, and tail. e Classification of cholesterol analogs- Group I-9,10-secosteroids, Group II-C-24 alkyl steroids, Group III-pentacyclic steroids. Structural variations from cholesterol are highlighted in red. f Cholesterol analogs were screened for particle size (nm), mRNA encapsulation (percent), and transfection efficiency (200 ng mRNA). Transfection experiments were conducted with n = 3. Source data are provided as a Source Data file.