Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;10:3054. doi: 10.1038/s41598-020-59888-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Dose dependent study of P188 on brain endothelial cell viability and modulated permeability coefficient. (a) Cell viability was measured after 24 h with MTT assay. Data represent mean ± SD from 6 independent experiments. *p < 0.05 when compared to the control (no P188 applied). (b) Changes in the permeability coefficients of the monolayer exposed to microcavitation and treated with P188 using 3 or 10 kDa Dextran molecules. *p < 0.05 compared to control (EC monolayer) from 6 independent experiments (n = 6). (c) Expansion of the crater if left untreated. Cells were exposed to microcavitation and incubated in serum-free media for 1 h and stained for ZO-1 (green) and nuclei (blue). (d) The crater expansion is prevented if the cells were treated with P188 (500 μm) for 6 hrs following microcavitation. Immunofluorescent images showed reconstitution of the tight junctions in response to P188.