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. 2020 Feb 20;11:971. doi: 10.1038/s41467-020-14776-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Hierarchical clustering of RNA-Seq expression data after filtering by expression level. b Relative expression of 10 candidate CYPs and triptolide concentration in RNAi suspension cells. c Co-expression of CYP728B70 and TwCPR3 in miltiradiene engineering yeast. d In vivo transformation of authentic diterpene alcohol substrates to the corresponding alcohols and acids in cultures of yeast cells expressing CYP728B70. e In vivo transformation of authentic diterpene substrates to the corresponding alcohols and acids in cultures of yeast cells expressing CYP728B70. f Relative expression of CYP728B70, as well as triptolide concentration in CYP728B70-overexpressing suspension cells on the 3rd, 5th, 7th, 9th day. Error bars, mean ± SD (n = 3 biologically independent samples; *P < 0.05, **P < 0.01 by 2-sided Student’s t test). Source data underlying Figs. 3a, b, f are provided as a Source Data file.