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. 2020 Feb 20;10:3009. doi: 10.1038/s41598-020-59514-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially regulated canonical pathways from Ingenuity Pathway Analysis. (A) The significance of each pathway (bar graphs; left y-axis), the log₂ fold-change (line graph; right y-axis), and z-score/activity pattern (bar color). (B) Stacked bar chart depicting the percentage (bar graph; left y-axis) of pathway components up-, down-, or not differentially expressed (bar color), with the number of pathway components given over each respective bar, and the significance of the differential regulation (line graph; right y-axis). Only transcripts with q < 0.05 were entered in the analysis; all pathways depicted exhibit p < 0.05.