Table 1.

Risk of worse breast cancer-specific or distant metastasis-free survival conferred by high protein levels HER3, EGFR, or HER3-EGFR protein expression in univariate Cox models stratified by hospital.

Biomarker	Chemo	Breast cancer-specific survival				Dstant metastasis-free survival
				95% CI for HR				95% CI for HR
		p-value	HR	Lower	Upper	p-value	HR	Lower	Upper
HER3	No	1.00	1.00	0.52	1.92	0.81	0.93	0.51	1.69
	Yes	0.41	1.31	0.69	2.47	0.58	1.19	0.63	2.25
EGFR	No	0.91	1.03	0.58	1.84	0.80	1.08	0.62	1.86
	Yes	0.63	1.13	0.69	1.84	0.10	1.48	0.92	2.38
HER3-EGFR	No	0.97	1.01	0.55	1.84	0.89	0.96	0.55	1.68
	Yes	0.003	2.50	1.38	4.53	0.022	1.95	1.10	3.43

HR = Hazard Ratio, CI = Confidence Interval.